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Safety guide for adults 18+
Spicy Cubes side effects: what is documented and who should ask first
We found no published study of the gummy itself, so we cannot give you a side-effect rate for Spicy Cubes. Reactions are documented for the plants in it, including heartburn, sweating, a rapid irregular heartbeat and allergies, with cautions for blood-pressure medicines, nitrates, blood thinners and diabetes medicines. Ask a doctor or pharmacist first if you are pregnant, breastfeeding, under 18, have a heart condition or take any medicine.
When should you stop and get urgent medical help?
Emergency guidance
Stop taking Spicy Cubes and call your local emergency number (911 in the US, 999 in the UK) if you have difficulty breathing, swelling of the face, lips, tongue or throat, a rash with dizziness or fainting, chest pain, a rapid irregular heartbeat, or bleeding that will not stop. Do not wait to see whether it passes.
What are the Spicy Cubes side effects?
The table lists what sources report for each plant, usually from other products and amounts. Treat it as a watch-list, not a prediction. For the label amounts, see our Spicy Cubes ingredients guide.
Plant
Reactions documented in the sources
Chili pepper
Heat in the mouth, leg cramps, bowel irregularities, rash and skin wheals. A 2022 umbrella review reported no serious adverse effects for spicy food, and links high capsaicin doses to neurotoxicity, redness and allergies.
Maca
Memorial Sloan Kettering (MSK) lists subjective reports of altered menstrual cycles, moodiness, cramps, gastritis and insomnia, and one case of prolonged bleeding between periods, in its clinician section. Its patient section says side effects have not been reported. No trial in a 2010 review assessed adverse effects.
Muira puama
EBSCO says significant side effects do not seem common, but that no comprehensive formal safety evaluation has been conducted.
Epimedium (horny goat weed)
MSK lists sweating or feeling hot, rapid irregular heartbeat, more energy and mood changes. WebMD adds dry mouth, nausea, vertigo and serious allergic reactions. A 2024 review of Epimedium koreanum, one species, reported potential liver toxicity from crude extracts; we do not know which species is in the gummy.
Ginger
NCCIH lists abdominal discomfort, heartburn, diarrhea and mouth and throat irritation. MSK adds skin irritation and case reports of nosebleeds and other bleeding.
Who should ask a doctor or pharmacist before taking Spicy Cubes?
Ask first if any of these apply. They are reasons to ask, not diagnoses.
- Pregnant or breastfeeding. Sources differ by plant; see the next section.
- Under 18. Spicy Cubes is for adults 18 and over. Keep it out of reach of children.
- A heart condition, an irregular heartbeat, or high or low blood pressure. MSK lists heart disease under "do not take" for epimedium.
- Any medicine, including a nitrate. See the medicine table below.
- A hormone-sensitive condition, such as breast or uterine cancer. MSK says to avoid epimedium with hormone-sensitive cancers and to ask first about maca.
- A bleeding disorder, gallstones or planned surgery. MSK says to avoid ginger supplements with the first two and to stop them 2 weeks before surgery.
- Liver or kidney disease. EBSCO says muira puama should not be used by people with severe liver or kidney disease.
- Any allergy. Serious allergic reactions are documented for epimedium. We do not hold a full allergen statement, so email us before you order.
Are Spicy Cubes safe during pregnancy or breastfeeding?
We cannot say they are safe, and we found no study of the gummy in pregnancy or breastfeeding. Ask your doctor, midwife or pharmacist first, and do not start in the meantime. Here is what each source says:
- Maca. MSK says it may not be safe if you are pregnant or breastfeeding.
- Epimedium. RxList says it is unsafe in pregnancy. WebMD says it is not known whether it could affect pregnancy or pass into breast milk.
- Muira puama. EBSCO says pregnant or nursing women should not use it.
- Ginger. MSK says to avoid ginger supplements in pregnancy or lactation. NCCIH says they may be safe in pregnancy and advises asking a provider.
Can you take Spicy Cubes with blood pressure medicine or other medicines?
Ask your doctor or pharmacist before combining Spicy Cubes with any medicine. FDA says some supplements might interact with medicines, and this table is not complete: RxList lists moderate interactions between epimedium and at least 26 drugs.
Medicine or group
Plant
What a source says
Nitrates, such as nitroglycerin; erectile dysfunction or pulmonary arterial hypertension medicines
Epimedium
WebMD lists these among the medicines to discuss with a provider before use.
Blood-pressure medicines
Maca; epimedium
MSK: in rats, maca strengthened the blood-pressure-lowering effect of losartan; relevance to people is unknown. RxList: epimedium might lower blood pressure, and might drop it too low in people who already have low blood pressure.
Blood thinners (anticoagulants) and NSAID painkillers
Ginger; epimedium
MSK: ginger supplements may raise the risk of bleeding with warfarin or NSAIDs. RxList: epimedium slows blood clotting and might increase the risk of bleeding.
Diabetes medicines, including insulin
Ginger
MSK: ginger supplements may cause larger reductions in glucose levels.
Hormone therapy, birth control, aromatase inhibitors
Epimedium
WebMD: discuss hormone therapy and birth control with your provider first. MSK lists aromatase inhibitors under "do not take": epimedium may reduce their effect, relevance not known.
Tacrolimus, cyclosporine, CYP3A4 medicines
Ginger; epimedium
MSK: ginger raised tacrolimus and lowered cyclosporine levels; prolonged epimedium use can induce CYP3A4. Relevance not known.
A medicine missing from the table is not cleared. Do not stop or change a prescribed medicine without asking your prescriber. Mention Spicy Cubes before blood tests too: MSK notes maca may interfere with lab tests that measure testosterone.
What about alcohol, anxiety and drug tests?
We found no data on any of these for the gummy, and we will not guess.
- Alcohol. None of the sources we opened covers these plants with alcohol. If you drink or take any medicine, ask your pharmacist.
- Anxiety. No source we opened measures how often these plants cause anxiety. A 2014 assessment of online sources and the literature reported mood changes, anxiety and hallucinations with products containing maca or horny goat weed (epimedium); it is weak evidence. If your heart races, treat it as urgent.
- Drug tests. We hold no data on whether any ingredient could affect a drug test. If you are tested for work or sport, ask the testing body first.
What do regulators warn about hidden drugs in supplements?
We are not saying Spicy Cubes contains any undeclared ingredient. We do not yet hold an independent batch report, so we cannot show a test result that rules one out. FDA warns that many products sold for sexual enhancement are likely to be contaminated with dangerous hidden ingredients, and says its list covers only a small fraction of contaminated products: absence from it does not mean a product is safe. One FDA notice reports tadalafil, not on the label, in a gummy sold for sexual enhancement; FDA says it may interact with nitrates (found in some prescription drugs, such as nitroglycerin) and lower blood pressure to dangerous levels.
If you take a nitrate, speak to your prescriber before using any gummy sold for sexual health, and use our buyer's checklist before you buy one.
How do you report a side effect from Spicy Cubes?
For milder reactions, such as heartburn, a rash, dizziness or trouble sleeping, stop taking the gummies and speak to a doctor or pharmacist. Keep the pouch, note what you took and when, then report it.
If you think a gummy may have caused a serious reaction, stop taking it, get medical help, and report it afterwards. FDA's guidance on reporting a supplement problem lists fainting, palpitations, severe, persistent vomiting or diarrhea, dark urine, yellowing of the skin or eyes, blood in urine, stool or vomit, and abnormal bleeding from the nose or gums as examples of serious reactions. Consumers can file a report.
- United States. File a report through FDA's Safety Reporting Portal at safetyreporting.hhs.gov, or call 1-888-INFO-FDA (1-888-463-6332). Partial information still helps.
- United Kingdom. Tell your GP or pharmacist. If you think a product is a suspicious medicine, or is sold by a suspicious website, the MHRA takes reports through its Yellow Card scheme.
- Canada. Anyone can report a side effect to a health product to Health Canada through its side-effect reporting page.
- Elsewhere. Ask your pharmacist which regulator takes reports.
- Us. Email contact@satiovex.com or call +1 307-400-8970; we reply within 1 to 2 business days. This does not replace seeing a clinician. For a refund, email us before sending anything back (shipping and returns).
Questions about Spicy Cubes safety
Are Spicy Cubes safe, including for diabetics, heart patients or people with high blood pressure?
We cannot call them safe for anyone with a health condition. Ask first, and check the medicine table above.
Is natural the same as safe?
No. FDA's guidance on products with hidden ingredients says the words "herbal" or "all natural" on a label do not mean the product is safe.
Do reviews and videos show Spicy Cubes side effects?
Not reliably. Spicy Cubes is a name more than one seller uses, and the formulas we have read differ, so a reaction someone describes may not be about this gummy.
Are Spicy Cubes a medicine or a drug?
Spicy Cubes is sold as a food supplement, not a medicine, and is not intended to diagnose, treat, cure or prevent any disease. For the legal question, see Is Spicy Cubes real?
Can anyone under 18 take Spicy Cubes?
No. It is sold to adults aged 18 and over only.
Sources
- FDA, Supplement questions and answers (2026)
- FDA, Reporting a supplement problem (2025)
- FDA, Sexual enhancement product notifications (2026)
- FDA, hidden tadalafil in a gummy (2024, 2025)
- FDA, Avoiding hidden ingredients (2025)
- Health Canada, Side effect reporting (2023)
- MHRA, illegal medicines press release (2026)
- MSK, Epimedium (2023)
- MSK, Maca (2023)
- MSK, Ginger (2022)
- NCCIH, Ginger (2025)
- Umbrella review of spicy food, Mol Nutr Food Res (2022)
- Shin et al., maca review, BMC CAM (2010)
- EBSCO, Muira puama (2024)
- Qian et al., Epimedium koreanum review, J Ethnopharmacol (2024)
- Corazza et al., products sold online, BioMed Res Int (2014)
- WebMD, Horny goat weed (2025)
- RxList, Horny goat weed
- NHS, Anaphylaxis (2023)
- MedlinePlus, Anaphylaxis (2026)
Related guides
Not sure it is right for you? Ask first.
Talk to your doctor or pharmacist before you start, and bring the pouch or a photo of its Supplement Facts. Or read the guide to what Spicy Cubes are.