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Horny goat weed in Spicy Cubes, adults 18+
Horny goat weed benefits for women: what studies in women examined
Each 3 g Spicy Cubes gummy lists epimedium (horny goat weed) extract in an 810 mg blend with muira puama, maca and ginger extracts, and every amount is printed on the label, alongside chili pepper 30 mg and maca root 50 mg. Compare the Spicy Cubes bundles and prices: packs of 30, 90, 150 or 300 gummies, with free tracked shipping and a 30-day money-back guarantee. This guide covers the studies in women: two placebo-controlled trials in women after menopause, which measured bone density or bone markers, blood levels and side effects, and a 2025 meta-analysis of 10 bone trials.
By the Spicy Cubes editorial team at Xinop LLC, trading as Satiovex, the seller of Spicy Cubes. Last updated 16 October 2026. Information, not medical advice. How we research and review pages.
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5 pouches · USD 20.99 per 30 gummies · you save USD 69.98
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10 pouches · USD 17.50 per 30 gummies · you save USD 174.95
USD 174.95
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Horny goat weed benefits for women in short
- What was studied. Two placebo-controlled trials in women after menopause, lasting 6 weeks and 24 months, measured bone density or bone markers, blood levels and side effects.
- What the table lists. Each trial's participants, product, length and measures, plus a 2025 meta-analysis of 10 bone trials.
Spicy Cubes gummies are sold by Xinop LLC, trading as Satiovex; What are Spicy Cubes? explains the name. For the other plant in many of the same blends, see maca root research, trial by trial. For this plant on its own, see horny goat weed (epimedium) research.
In daily life
See Spicy Cubes in daily life
Pictures and clips are AI-generated illustrations; the people shown are not customers. The label on your pouch is the reference.
What does horny goat weed do for women? What trials in women measured
The table names what each trial measured, in whom and for how long.
Trial
Who took part
What they took, and for how long
What was measured, and notes
Zhang, Qin and Shi (2007), Journal of Bone and Mineral Research
100 healthy women, 10 to 18 years after menopause; 85 finished
A flavonoid preparation made from the plant (60 mg icariin, 15 mg daidzein and 3 mg genistein a day) plus 300 mg calcium for everyone, against placebo; 24 months
Bone density, bone markers, blood estradiol and thickness of the womb lining. A mix, not the plant alone. The abstract states no limits and we did not read the full text.
Yong and colleagues (2021), Phytomedicine
58 healthy women after menopause, average age 57.9; all completed
A purified Epimedium extract, 740 mg a day, against placebo; 6 weeks, with blood checks 2 weeks after stopping
Main outcomes: safety and blood levels of the extract's breakdown products. Also a bone marker and a protein called TRAF6. The authors write that safety, mechanisms and therapeutic indications in humans are unknown.
Zhang and colleagues (2025), Frontiers in Medicine: meta-analysis
890 adults with osteoporosis in 10 trials; 3 of the trials enrolled women only
Epimedium alone or with other treatments, against placebo, calcium or other treatments; products and course lengths varied
Bone density, bone markers, back pain and side effects. Only 2 of the 10 trials were rated low risk of bias overall. The authors say more high-quality studies are needed.
The table is not a list of every study. It covers the two women-only trials that the meta-analysis rated low risk of bias overall. Its third women-only trial (2003, 25 women, Epimedium against conjugated estrogen) is known to us only from its table.
What do the sources say about other uses in women?
MSK describes two traditional uses without confirming either. Fatigue, it says, has not been studied in clinical trials. Sexual dysfunction is a traditional use in herbal formulas, and MSK says more studies are needed to verify such effects.
Does horny goat weed have estrogen-like activity?
Cells, animals and women have been studied differently, so the findings are kept apart.
- In cells. MSK says icariin, a main compound in the plant, raises estrogen production and the expression of aromatase, an enzyme involved in making estrogen, in laboratory experiments. Other studies credit estrogen-like activity to two related compounds, icaritin and desmethylicaritin, rather than to icariin itself.
- In animals. The 2026 review describes an extract given to female rats whose ovaries had been removed, and reports results for bone density and for blood estradiol and two bone proteins.
- In women. One trial measured blood estradiol and the thickness of the womb lining in women taking a flavonoid mix. Its abstract says neither was found to be changed in either group.
Can women take horny goat weed?
Spicy Cubes is for adults 18 and over; follow the directions on the pouch. For the plant on its own, MSK's public page shows no dose (its Dosage section is marked OneMSK Only), and WebMD says to follow the directions on the specific product or take it as your health care provider recommends.
The trials above used 740 mg a day of an extract for 6 weeks and a flavonoid mix for 24 months: the researchers' choices for their own products.
NCCIH's general advice for any supplement is to follow the instructions on the label. For food and time of day, see what labels and studies say about timing.
Where Spicy Cubes fits
Spicy Cubes is a botanical gummy for adults 18+, sold by Xinop LLC, trading as Satiovex. Each 3 g gummy lists chili pepper 30 mg, maca root 50 mg and an 810 mg blend of muira puama, epimedium, maca and ginger extracts. See the label, packs and 30-day guarantee.
The label gives the 810 mg blend as one combined amount. Spicy Cubes is a food supplement, so no medical claims are made for it.
Spicy Cubes ingredients explains the label plant by plant, and the couples guide explains what "for couples" means on a label.
Ingredient guides: what the research says, plant by plant
Maca root
50 mg per gummy on the label, plus a 4:1 extract in the blend. We read eight human trials and report what each measured.
Ginger root
A 4:1 extract in the blend. Chili pepper is listed separately at 30 mg per gummy.
Good to know before you start
When to ask your doctor or pharmacist first
For adults 18 and over. Follow the directions on the pouch. Ask your doctor or pharmacist first if you are pregnant or nursing, take any medicine (especially nitrates, blood-pressure medicine, blood thinners, aromatase inhibitors, birth control or other hormone therapy) or have a medical condition such as heart disease or a hormone-sensitive cancer. If you have side effects, stop taking it and contact your health care provider, as NCCIH advises for any supplement. Research on horny goat weed on its own is still early: MSK calls the evidence limited, and a 2026 review says robust clinical evidence is still lacking.
What the sources name
The sources we opened name the groups below; a doctor or pharmacist who knows your medicines can check your case.
- If you have a hormone-sensitive cancer. MSK's patient page says epimedium may affect hormone levels and should be avoided in patients with hormone-sensitive cancers or heart disease, and its clinician section advises caution because it demonstrated estrogenic effects. WebMD asks you to tell your provider about hormone-sensitive cancer, such as breast or ovarian cancer, and about menopause.
- If you take cancer hormone treatment, hormone therapy or birth control. MSK says icariin raised the action of aromatase in lab work, which may reduce the effect of aromatase inhibitors such as anastrozole, exemestane and letrozole; clinical relevance is not known. WebMD lists hormone therapy and other medicines that contain hormones, such as birth control, among the things to discuss, and says the research on drug interactions is incomplete.
- If you have a heart condition or take nitrates. MSK describes a patient with heart disease in whom epimedium caused rapid irregular heartbeat and excitability. WebMD says to ask your provider about nitrates such as nitroglycerin and about PDE5-inhibitor medicines or medicines for pulmonary arterial hypertension.
- If you take a blood thinner or have surgery planned. NCCIH says certain dietary supplements may raise the risk of bleeding or affect your response to anesthesia. A pharmacist can check your medicines.
- If you take any prescription medicine. MSK says prolonged use of Epimedium can induce CYP3A4, an enzyme that processes many drugs, and that clinical relevance is not known. WebMD says to check with your health care provider before taking horny goat weed with any medicines.
Pregnancy and breastfeeding
WebMD says it is not known if or how it could affect pregnancy or harm an unborn baby, or whether it passes into breast milk. MSK's page does not address either. NCCIH says many dietary supplements have not been studied in pregnant women, nursing mothers or children.
NCCIH also warns that some products promoted for sexual use, among others, may contain prescription drugs not allowed in dietary supplements. Horny goat weed side effects and interactions covers hidden drugs and the side effects on record.
Lab values reported in the trials
An abstract does not always match later accounts of the same trial. Yong's abstract reports no changes in liver, blood or kidney tests, while the meta-analysis describes a few values above the normal range, such as alkaline phosphatase more than 30% above the upper limit in four women. All later returned to normal.
Details: Spicy Cubes side effects
Horny goat weed benefits for women: questions people ask
What does horny goat weed do for women?
Spicy Cubes is a food supplement, so no medical claims are made for it. Every amount is printed on the label (chili pepper 30 mg, maca root 50 mg and an 810 mg blend of muira puama, epimedium, maca and ginger extracts per 3 g gummy), and a 30-day money-back guarantee covers your order. The two trials in women described above measured bone density or bone markers, blood levels and side effects in women after menopause. See Spicy Cubes ingredients.
Does horny goat weed increase estrogen in women?
In cells, MSK says icariin raises estrogen production. In one trial in women, blood estradiol was reported unchanged in both groups. The section above sets out the cell, animal and human findings.
How much do Spicy Cubes gummies cost?
Packs start at USD 34.99 for 30 gummies. A pack of 90 (buy 2, get 1 free) is USD 69.98, 150 (buy 3, get 2 free) is USD 104.97 and 300 (buy 5, get 5 free) is USD 174.95. Shipping is free and tracked, and a 30-day money-back guarantee covers your order. See the packs and prices.
Does horny goat weed help bone density after menopause?
Two trials in women after menopause measured bone density (100 women, 24 months, a flavonoid mix) or a bone marker (58 women, 6 weeks, an extract), and a 2025 meta-analysis pooled 10 bone trials. See horny goat weed (epimedium) research for the wider research.
Where can I buy Spicy Cubes, and how long does delivery take?
Spicy Cubes gummies on this site are sold by Xinop LLC, trading as Satiovex. Shipping is free and tracked, orders are dispatched within 1 working day, and delivery estimates are 4 to 5 working days in the UK and 5 to 8 working days in other countries we ship to. A 30-day money-back guarantee covers your order. See where to buy Spicy Cubes.
What is the horny goat weed in Spicy Cubes?
Each 3 g Spicy Cubes gummy contains epimedium extract (10:1) as part of an 810 mg blend with maca, muira puama and ginger extracts; chili pepper (30 mg) and maca root (50 mg) are listed separately. The full table is on Spicy Cubes ingredients, and the label checklist for horny goat weed gummies covers how gummy labels list their amounts.
How we checked this page
For horny goat weed benefits for women, we describe only what the studies we opened measured, and we list every source below.
Primary sources, all linked
This page lists 10 sources: the pages, records and studies we opened, each with its own date where the publisher gives one. Our editorial team opened each one, and we tested every link on 8 October 2026.
How to read these studies
Each study covers one plant at a stated dose, so we report what studies measured and in whom, and make no claims about what a gummy will do.
Who sells Spicy Cubes
Spicy Cubes gummies on this site are sold by Xinop LLC, trading as Satiovex, 8206 Louisiana Blvd NE, Albuquerque, NM 87113, USA. Email contact@satiovex.com or call +1 307-400-8970; we reply within 1 to 2 business days.
Who writes this
The Spicy Cubes editorial team at Xinop LLC (trading as Satiovex), which sells Spicy Cubes gummies. This page is information, not medical advice. To report an error, email contact@satiovex.com: we correct it and note the date.
Read our editorial policy and the independent seller notice.
Sources
- Memorial Sloan Kettering, About Herbs: Epimedium (updated 5 April 2023)
- WebMD, Horny Goat Weed: Uses, Side Effects, and More (medically reviewed 8 August 2025)
- NIH NCCIH, Using Dietary Supplements Wisely (2019)
- Zhang, Qin and Shi, Journal of Bone and Mineral Research (2007), 24-month placebo-controlled trial in 100 women
- Yong et al., Phytomedicine (2021), placebo-controlled trial in 58 women
- Zhang et al., Frontiers in Medicine (2025), meta-analysis of Epimedium in primary osteoporosis
- Friș et al., Plants (2026), review of Epimedium species
- PubMed search, 7 October 2026: the plant's names, women, sexual-function terms, clinical trials only
- PubMed search, 7 October 2026: the plant's names with pregnancy, breastfeeding or lactation, humans
- PubMed search, 7 October 2026: the plant's names with blood thinners, bleeding or clotting, humans
Related guides
Horny goat weed (epimedium)
What the human trials and laboratory studies cover.
When to take horny goat weed
What labels and studies say about timing.
Choose your Spicy Cubes bundle
90 gummies
Buy 2, get 1 free
3 pouches · USD 23.33 per 30 gummies · you save USD 34.99
USD 69.98
Buy nowBest value
150 gummies
Buy 3, get 2 free
5 pouches · USD 20.99 per 30 gummies · you save USD 69.98
USD 104.97
Buy now 300 gummies
Buy 5, get 5 free
10 pouches · USD 17.50 per 30 gummies · you save USD 174.95
USD 174.95
Buy nowPrices in USD; your local currency is shown at checkout. Free tracked shipping and a 30-day money-back guarantee. Sold by Xinop LLC, trading as Satiovex. Adults 18+ only.
Questions about Spicy Cubes? Ask us.
Questions about Spicy Cubes? Email contact@satiovex.com and we reply within 1 to 2 business days.
